Definition

Sjogren syndrome is asystemic inflammatory disorder characterized by dry mouth, decreased tearing, and other dry mucous membranes. It is often associated with autoimmune rheumatic disorders.

Causes

The cause of Sjogren syndrome is unknown. The syndrome occurs most often in women 40 to 50 years old. It is rare in children. Pediatric patients usually present with anotherautoimmune disorder before developing the signs of Sjogren syndrome.

Dryness of the eyes and mouth are the most common symptoms of this syndrome; they may occur alone, or with symptoms associated with rheumatoid arthritis or other connective tissue diseases. There may be an associated enlargement of the salivary glands. Other organs may become affected. The syndrome may be associated with rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, and other diseases. Sjogren syndrome affects 3% of the population.

Review Date: 8/3/2003
Reviewed By: Megan Clowse, M.D., Division of Rheumatology, Johns Hopkins Hospital, Baltimore, MD. Review provided by VeriMed Healthcare Network.