Primary biliary cirrhosis

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Digestive system


Bile pathway

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Primary biliary cirrhosis

Definition

Primary biliary cirrhosis is an inflammation (irritation and swelling) of the bile ducts of the liver resulting in narrowing and obstruction of the flow ofbile. This obstruction damages liver cells.

Alternative Names

PBC

Causes

The cause of inflamed bile ducts within the liver in this condition is not known. The disease more commonly affects middle-aged women. The onset of symptoms is gradual, with fatigue and itching skin as the most common first symptom.

Long-standing bile obstruction is believed to lead to liver cirrhosis. The disease may be associated with autoimmune disorders such as hypothyroidism, Raynaud's, CREST syndrome, and arthridities. There are about 3 to 15 cases per million people in the U.S. population each year.

Review Date: 5/14/2004
Reviewed By: Christian Stone, M.D., Division of Gastroenterology, Washington University in St. Louis School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network.

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