EstradiolEstradiol

Estradiol Acetate Oral tablet

What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have or ever had any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. To reduce nausea, this medicine may be taken with food. Follow the directions on the prescription label. Take this medicine at the same time each day and in the order directed on the package. Do not take your medicine more often than directed.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates or benzodiazepines used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.


Estradiol Acetate Vaginal insert

What is this medicine?

ESTRADIOL (es tra DYE ole) vaginal ring is an insert that contains a female hormone. This medicine helps relieve symptoms of vaginal irritation and dryness that occurs in some women during menopause. This medicine can also help relieve hot flashes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine may be inserted by you or your physician. Follow the directions that are included with your prescription. If you are unsure how to insert the ring, contact your doctor or health care professional. The vaginal ring should remain in place for 90 days. After 90 days you should replace your old ring and insert a new one. Do not stop using except on the advice of your doctor or health care professional.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone, vorozole

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

You may bathe or participate in other activities while using this medicine. You do not need to remove the vaginal ring during sexual or other activities unless you are more comfortable doing so. Within the 90-day dosage period, you may remove the vaginal ring, rinse it with clean lukewarm (not hot or boiling) water, and re-insert the ring as needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Cypionate Solution for injection

What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is used to treat the symptoms of low hormone levels in menopausal women. It is used to treat women who have had their ovaries removed or who have ovaries that do not work well. It helps to treat hot flashes and vaginal problems. It is also used to treat men with some kinds of prostate cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have or ever had any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • cancer

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high level of calcium in the blood

  • hysterectomy

  • protein C deficiency

  • protein S deficiency

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is usually given by a health care professional in a hospital or clinic setting.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates or benzodiazepines used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, let your doctor know you are receiving estrogen. Consult your health care professional for advice before you schedule the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.


Estradiol Oral tablet

What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have or ever had any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. To reduce nausea, this medicine may be taken with food. Follow the directions on the prescription label. Take this medicine at the same time each day and in the order directed on the package. Do not take your medicine more often than directed.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates or benzodiazepines used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date.


Estradiol Topical emulsion

What is this medicine?

ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like vaginal dryness, itching and increased or painful urination.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Use exactly as directed. Two packets of estradiol topical emulsion contain enough medication for one day. Allow the emulsion to dry completely before covering with clothing. After you apply the emulsion to your legs wash both hands with soap and water to remove any residual emulsion. Do not use your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine

  • raloxifene or tamoxifen

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • breakthrough bleeding and spotting

  • breast tissue changes or discharge

  • chest pain

  • confusion, forgetfulness

  • leg, arm or groin pain

  • nausea, vomiting

  • severe headaches

  • speech problems

  • stomach pain (severe)

  • sudden shortness of breath

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in emotions or mood

  • changes in sex drive or performance

  • increased or decreased appetite

  • skin rash, acne, or brown spots on the skin

  • symptoms of a vaginal infection like itching, irritation or unusual discharge

  • weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Topical gel

What is this medicine?

ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause like hot flashes, night sweats, and mood changes. This medicine may also help relieve other symptoms like vaginal dryness, itching and increased or painful urination.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions that come with your prescription. Spread the gel into a thin layer. It is not necessary to rub or massage the gel into the skin. Wash your hands with soap and water after applying the gel. Allow the gel to dry for up to 5 minutes before dressing. Avoid fire, flame or smoking until gel has dried. Do not apply to the breast, face or in or around the vagina. Do not use your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine

  • raloxifene or tamoxifen

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • breakthrough bleeding and spotting

  • breast tissue changes or discharge

  • chest pain

  • confusion, forgetfulness

  • leg, arm or groin pain

  • nausea, vomiting

  • severe headaches

  • speech problems

  • stomach pain (severe)

  • sudden shortness of breath

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in emotions or mood

  • changes in sex drive or performance

  • increased or decreased appetite

  • skin rash, acne, or brown spots on the skin

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • weight gain

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Topical solution, spray

What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. This medicine helps relieve symptoms of menopause such as hot flashes, night sweats, and mood changes.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Your health care provider will show you how to apply this medicine. Apply this medicine at the same time each day to clean, dry, unbroken skin on the inside of the forearm between the elbow and the wrist. If you take a bath or shower or use a sauna, apply this medicine after the bath, shower, or sauna, and once the skin is dry. Avoid fire, flame or smoking until the spray has dried. Do not apply to the breast. Do not use your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, skip the missed dose and get back on your normal schedule. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentine

  • antiviral medicines for HIV or AIDS

  • certain antibiotics like erythromycin and clarithromycin

  • carbamazepine

  • grapefruit juice

  • medicines for fungal infections like ketoconazole and itraconazole

  • phenobarbital

  • raloxifene

  • tamoxifen

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

This medicine can transfer from your body to others. If a person or pet comes in contact with the area where this medicine was applied to your skin, they may have a serious risk of side effects. If you cannot avoid skin-to-skin contact with another person, make sure the site where this medicine was applied is covered with clothing. If accidental contact happens, the skin of the person or pet should be washed right away with soap and water.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • irritation or mild redness at the application site

  • symptoms of vaginal infection like itching, irritation or unusual discharge

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Transdermal patch - 24 hour

What is this medicine?

ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, apply only that dose. Do not apply double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

You may bathe or participate in other activities while wearing your patch. If the patch pulls loose or falls off, you may reapply it if the patch is sticky enough to stay on the skin. You should reapply the patch in a different area. Use a fresh patch if it will no longer stick.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.


Estradiol Transdermal patch - biweekly

What is this medicine?

ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, apply only that dose. Do not apply double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

You may bathe or participate in other activities while wearing your patch. If the patch pulls loose or falls off, you may reapply it if the patch is sticky enough to stay on the skin. You should reapply the patch in a different area. Use a fresh patch if it will no longer stick.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.


Estradiol Transdermal patch - weekly

What is this medicine?

ESTRADIOL (es tra DYE ole) skin patches contain an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for external use only. Follow the directions on the prescription label. Tear open the pouch, do not use scissors. Remove the stiff protective liner covering the adhesive. Try not to touch the adhesive. Apply the patch, sticky side to the skin, to an area that is clean, dry and hairless. Avoid injured, irritated, calloused, or scarred areas. Do not apply the skin patches to your breasts or around the waistline. Use a different site each time to prevent skin irritation. Do not cut or trim the patch. Do not stop using except on the advice of your doctor or health care professional. Do not wear more than one patch at a time unless you are told to do so by your doctor or health care professional.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, apply it as soon as you can. If it is almost time for your next dose, apply only that dose. Do not apply double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery or an MRI, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

You may bathe or participate in other activities while wearing your patch. If the patch pulls loose or falls off, you may reapply it if the patch is sticky enough to stay on the skin. You should reapply the patch in a different area. Use a fresh patch if it will no longer stick.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 30 degrees C (86 degrees F). Do not store any patches that have been removed from their protective pouch. Throw away any unused medicine after the expiration date. Dispose of used patches properly. Since used patches may still contain active hormones, fold the patch in half so that it sticks to itself prior to disposal.


Estradiol Vaginal cream

What is this medicine?

ESTRADIOL (es tra DYE ole) contains the female hormone estrogen. It is used for symptoms of menopause, like vaginal dryness and irritation.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high levels of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, soy, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for use in the vagina only. Do not take by mouth. Follow the directions on the prescription label. Read package directions carefully before using. Use the special applicator supplied with the cream. Wash hands before and after use. Fill the applicator with the prescribed amount of cream. Lie on your back, part and bend your knees. Insert the applicator into the vagina and push the plunger to expel the cream into the vagina. Wash the applicator with warm soapy water and rinse well. Use exactly as directed for the complete length of time prescribed. Do not stop using except on the advice of your doctor or health care professional.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • barbiturates used for inducing sleep or treating seizures

  • carbamazepine

  • grapefruit juice

  • medicines for fungal infections like ketoconazole and itraconazole

  • raloxifene

  • rifabutin

  • rifampin

  • rifapentine

  • ritonavir

  • some antibiotics used to treat infections

  • St. John's Wort

  • tamoxifen

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine at once and contact your doctor or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from temperatures above 40 degrees C (104 degrees C). Do not freeze. Throw away any unused medicine after the expiration date.


Estradiol Vaginal insert

What is this medicine?

ESTRADIOL (es tra DYE ole) vaginal ring is an insert that contains a female hormone. This medicine helps relieve symptoms of vaginal irritation and dryness that occurs in some women during menopause.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine may be inserted by you or your physician. Follow the directions that are included with your prescription. If you are unsure how to insert the ring, contact your doctor or health care professional. The vaginal ring should remain in place for 90 days. After 90 days you should replace your old ring and insert a new one. Do not stop using except on the advice of your doctor or health care professional.

Contact your pediatrician regarding the use of this medicine in children. Special care may be needed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone, vorozole

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant, stop taking this medicine right away and contact your doctor or health care professional.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, you may need to stop taking this medicine. Consult your health care professional for advice before you schedule the surgery.

You may bathe or participate in other activities while using this medicine. You do not need to remove the vaginal ring during sexual or other activities unless you are more comfortable doing so. Within the 90-day dosage period, you may remove the vaginal ring, rinse it with clean lukewarm (not hot or boiling) water, and re-insert the ring as needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Vaginal tablet

What is this medicine?

ESTRADIOL (es tra DYE ole) vaginal tablet is used to help relieve symptoms of vaginal irritation and dryness that occurs in some women during menopause.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • breast, cervical, endometrial, ovarian, liver, or uterine cancer

  • dementia

  • diabetes

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high cholesterol

  • high level of calcium in the blood

  • hysterectomy

  • kidney disease

  • liver disease

  • migraine headaches

  • protein C deficiency

  • protein S deficiency

  • stroke

  • systemic lupus erythematosus (SLE)

  • tobacco smoker

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is only for use in the vagina. Do not take by mouth. Wash your hands before and after use. Read package directions carefully. Unwrap the pre-filled applicator package. Lie on your back, part and bend your knees. Gently insert the applicator tip high in the vagina and push the plunger to release the tablet into the vagina. Gently remove the applicator. Throw away the applicator after use. Do not use your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better. Do not stop using except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • antibiotics used to treat tuberculosis like rifabutin, rifampin and rifapentene

  • raloxifene or tamoxifen

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your health care professional for regular checks on your progress. You will need a regular breast and pelvic exam. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

If you have any reason to think you are pregnant; stop taking this medicine at once and contact your doctor or health care professional.

Tobacco smoking increases the risk of getting a blood clot or having a stroke, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist.

If you are going to have elective surgery, you may need to stop taking this medicine beforehand. Consult your health care professional for advice prior to scheduling the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.


Estradiol Valerate Oil for injection

What is this medicine?

ESTRADIOL (es tra DYE ole) is an estrogen. It is used to treat the symptoms of low hormone levels in menopausal women. It is used to treat women who have had their ovaries removed or who have ovaries that do not work well. It helps to treat hot flashes and vaginal problems. It is also used to treat men with some kinds of prostate cancer.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have or ever had any of these conditions:

  • abnormal vaginal bleeding

  • blood vessel disease or blood clots

  • cancer

  • gallbladder disease

  • heart disease or recent heart attack

  • high blood pressure

  • high level of calcium in the blood

  • hysterectomy

  • protein C deficiency

  • protein S deficiency

  • an unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle. It is usually given by a health care professional in a hospital or clinic setting.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

  • aromatase inhibitors like aminoglutethimide, anastrozole, exemestane, letrozole, testolactone

This medicine may also interact with the following medications:

  • carbamazepine

  • certain antibiotics used to treat infections

  • certain barbiturates or benzodiazepines used for inducing sleep or treating seizures

  • grapefruit juice

  • medicines for fungus infections like itraconazole and ketoconazole

  • raloxifene or tamoxifen

  • rifabutin, rifampin, or rifapentine

  • ritonavir

  • St. John's Wort

  • warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need a regular breast and pelvic exam and Pap smear while on this medicine. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests.

This medicine can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your doctor or health care professional if you feel you are retaining fluid.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Smoking increases the risk of getting a blood clot or having a stroke while you are taking this medicine, especially if you are more than 35 years old. You are strongly advised not to smoke.

If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye doctor or health care professional.

This medicine can increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with this medicine lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.

If you are going to have surgery, let your doctor know you are receiving estrogen. Consult your health care professional for advice before you schedule the surgery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • breast tissue changes or discharge

  • changes in vision

  • chest pain

  • confusion, trouble speaking or understanding

  • dark urine

  • general ill feeling or flu-like symptoms

  • light-colored stools

  • nausea, vomiting

  • pain, swelling, warmth in the leg

  • right upper belly pain

  • severe headaches

  • shortness of breath

  • sudden numbness or weakness of the face, arm or leg

  • trouble walking, dizziness, loss of balance or coordination

  • unusual vaginal bleeding

  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • hair loss

  • increased hunger or thirst

  • increased urination

  • symptoms of vaginal infection like itching, irritation or unusual discharge

  • unusually weak or tired

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.


 
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